In 2012 TGL commissioned a refresh of all of the book cover designs by Suzy Tuxen and the team at A Friend of Mine. Each cover was themed with one colour.

Pink remained as the distinctive colour for Antibiotic Guidelines.

As new editions of each title were published, the new covers were gradually introduced. In 2019 the last two books with new covers will be printed for the first time: the third edition of Oral and Dental Guidelines and the third edition of Toxicology and Toxinology Guidelines (previously Toxicology and Wilderness Guidelines).